Butanediol induced ketosis increases tolerance to hypoxia in the mouse.
نویسندگان
چکیده
منابع مشابه
Butanediol induced ketosis increases tolerance to hypoxia in the mouse.
In previous studies from our laboratory a positive correlation between elevated blood ketone levels and the survival time (ST) during hypoxia (4-5% oxygen) was observed in fasted and alloxan diabetic mice. To test the hypothesis that ketosis was somehow increasing the tolerance of mice to hypoxia, we induced ketosis by either oral (PO), intraperitoneal (IP), or intravenous (IV) 1,3-butanediol (...
متن کاملReduction of neurologic deficit by 1,3-butanediol induced ketosis in levine rats.
The objective of this study was to determine if 1,3-butanediol would reduce a neurologic deficit in rats exposed to ischemic-hypoxia (Levine rats). Age and weight matched male Sprague-Dawley rats were anesthetized with 2% halothane. The right common carotid and external jugular vein were ligated and cannulated and EEG screws were implanted followed by a 2 hour recovery period. Thirty minutes pr...
متن کاملHypoxia-Induced Increases in Hypoxic Tolerance Augmented by /3-Hydroxybutyrate in Mice
A standard murine model was used to determine whether acute pretreatment exposures to hypoxia could alter ultimate hypoxic survival time. Adult male albino mice (Mus musculus) weighing 25-30 g were subjected to three pretreatment hypoxic exposures (4.5% O2, balance N2) of increasing duration (90, 120, and 150 seconds) with 300 seconds of normoxia between each pretreatment exposure and before te...
متن کاملHypoxia-induced increases in hypoxic tolerance augmented by beta-hydroxybutyrate in mice.
A standard murine model was used to determine whether acute pretreatment exposures to hypoxia could alter ultimate hypoxic survival time. Adult male albino mice (Mus musculus) weighing 25-30 g were subjected to three pretreatment hypoxic exposures (4.5% O2, balance N2) of increasing duration (90, 120, and 150 seconds) with 300 seconds of normoxia between each pretreatment exposure and before te...
متن کاملHypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin.
BACKGROUND AND PURPOSE Cellular response to hypoxia is mainly controlled by hypoxia-inducible factor 1 (HIF-1). The HIF-1 target gene erythropoietin (EPO) has been described as neuroprotective. Thus, we hypothesize EPO to be an essential mediator of protection in hypoxic preconditioning. METHODS We randomized Sv129 mice into groups for different pretreatments, different hypoxia-ischemia inter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stroke
سال: 1980
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.11.5.506